New cytostatic drugs in ovarian cancer

Immunosuppression by cytostatic drugs?

In the present study, an attempt was made to characterize the immunomodulating abilities of the cytostatic drugs cyclophosphamide, ifosfamide, vinblastine, vincristine, procarbazine, dacarbazine, 6-mercaptopurine, methotrexate, 5-fluorouracil and adriamycin in a defined experimental model. Varying combinations of drug plus transplantation alloantigen, (C3H-lymphocytes) were injected into Balb/c...

NEw DRUGS IN THE TREATMENT OF Ovarian Cancer

Prostate cancer, miRNAs, metallothioneins and resistance to cytostatic drugs.

MicroRNAs (miRNAs) translationally repressing their target messenger RNAs due to their gene-regulatory functions play an important but not unexpected role in a tumour development. More surprising are the findings that levels of various miRNAs are well correlated with presence of specific tumours and formation of metastases. Moreover, these small regulatory molecules play a role in the resistanc...

Fertility drugs and ovarian cancer

Objective To examine the effects of fertility drugs on overall riskofovariancancerusingdata froma largecohort

Fertility drugs and ovarian cancer.

In 1992, a pooled analysis of the risk of ovarian cancer was published by Whittemore et al. (1). It received a great deal of attention because of its size and many strengths. The study confirmed most of the previously identified risk factors for ovarian cancer, but, in addition, a considerably increased risk of ovarian cancer was observed among infertile women who had used fertility drugs (1). ...